Davunetide

Pharmacology

• Davunetide is an octapeptide that promotes Microtubles assembly; in transgenic mice, it reduced tau phosphorylation and Aβ levels.
• Davunetide interacts with Microtubles
  1. preventing the formation of neurofibrillary tanges and protecting the network from a 'death signal' or
  2. repairing the network if the brain cell death process has already begun.

Recent collaborative studies demonstrated that (Davunetide) had a potent neuroprotective effect against ibotenate-induced excitotoxic damage in the cortical plate and the white matter of P5 mice, and moderate action against brain lesions of P0 mice.

One study [4] tested Davunetide's effect on schizophrenia, however it was not produce a relevant change.

Estimated human dose about 10mg?

Half life is short at ∼1h, but may have lasting effects.