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J147
B

Primary Mechanism ATP Synthase Inhibitor
Class Longetive, Nootropic
Drug Status Phase 1
Alternate Names J-147
Pubchem ID 25229652
Contributors @arche

Pharmacology

J147 is an inhibitor of ATP synthase and upregulates NGF, Egr, and AMPK. It is a synthetic analog of curcumin [1], and has completed Phase 1 human trials (but with limited information).

Besides neurotrophic and neuroprotective effects, J147 has demonstrated appreciable bioavailability and safety over curcumin [2]. The oral bioavailability and t1/2 of J147 in mice are 28% and 2.5 h, respectively [3][4]

J147 has been found to:

  • Whiten skin via suppressing α-MSH induced melanogenesis [2]
  • Upregulate 5-HT1A (and have an antidepressant effect) [5]

Note: There is a derivative of J147 called T-006.

Sources

[ 1 ] Current evidence for J147 as a potential therapeutic agent in nervous system disease: a narrative review
[ 2 ] The Inhibitory Effect of Curcumin Derivative J147 on Melanogenesis and Melanosome Transport by Facilitating ERK-Mediated MITF Degradation
[ 3 - Sci-Hub ] Metabolism of a potent neuroprotective hydrazide
[ 4 ] The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice
[ 5 ] Sub-Acute Treatment of Curcumin Derivative J147 Ameliorates Depression-Like Behavior Through 5-HT1A-Mediated cAMP Signaling

Related

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