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Oroxylin A
B

Primary Mechanism DRI, GABA-A NAM, A2A Enhancer
Class Nootropic, Longetive
Drug Status Naturally Derived
Alternate Names Sabroxy
Pubchem ID 5320315
Contributors @arche

Pharmacology

Oroxylin A, the main constituent of Sabroxy (10% Oroxylin A), is a naturally-derived flavone, notably found in the Oroxylum indicum tree [1].

It has demonstrated activity as a dopamine reuptake inhibitor [2] (and D1 enhancer), and is also a negative allosteric modulator (NAM) of the benzodiazepine site of the GABAA receptor [3]. In addition, Oroxylin A has been found to improve memory consolidation in mice by elevating brain-derived neurotrophic factor (BDNF) levels in the hippocampus [4]. It is thought to do this by enhancing A2A receptors [6].

It has also been found to protect against Abeta(25-35) memory impairments in mice [5].

It is commonly used at doses in the milligram range (e.g 10-30mg sublingually), and for Sabroxy extract, the dosage is multiplied 10x (however it is noted as less effective).

It has been noted to have a half life of about 4 to 6 hours.

Sources

[ 1 - Sci-Hub ] The constitution of oroxylin-A, a yellow colouring matter from the root-bark of Oroxylum indicum
[ 2 - Sci-Hub ] Oroxylin A improves attention deficit hyperactivity disorder-like behaviors in the spontaneously hypertensive rat and inhibits reuptake of dopamine in vitro
[ 3 - Sci-Hub ] Benzodiazepine binding site-interactive flavones from Scutellaria baicalensis root
[ 4 - Sci-Hub ] Oroxylin A enhances memory consolidation through the brain-derived neurotrophic factor in mice
[ 5 - Sci-Hub ] The effects of acute and repeated oroxylin A treatments on Abeta(25-35)-induced memory impairment in mice
[ 6 ] Oroxylin A Induces BDNF Expression on Cortical Neurons through Adenosine A2A Receptor Stimulation: A Possible Role in Neuroprotection

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