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SRT-2104

Primary Mechanism SIRT1 Activator
Class Longetive
Drug Status Phase 2
Alternate Names None
Pubchem ID 25108829
Contributors @arche

Pharmacology

SRT-2104 is a small-molecule activator of SIRT1. It is being researched for longevity and lifespan enhancement.

Apart from lifespan, it has also been researched for diabetes [2], osteoarthritis [1] and cognition [3].

SIRT1 Activation may be antidepressant and/or procognitive:

We show that ablation of SIRT1 in cortical and hippocampal glutamatergic neurons results in depression-like behaviors in male but not in female mice. [3]

SRT-2104 was well tolerated in phase II trials [2], but was discontinued due to efficacy in diabetes, however it still may have implications for human lifespan.

Sources

[ 1 ] Inhibition of Knee Osteoarthritis Progression in Mice by Administering SRT2104, an Activator of Silent Information Regulator 2 Ortholog 1
[ 2 ] A phase II, randomized, placebo-controlled, double-blind, multi-dose study of SRT2104, a SIRT1 activator, in subjects with type 2 diabetes
[ 3 ] SIRT1 in forebrain excitatory neurons produces sexually dimorphic effects on depression-related behaviors and modulates neuronal excitability and synaptic transmission in the medial prefrontal cortex

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