Zelquistinel

Pharmacology

Zelquistinel is a unique modulator of NMDA, modulating multiple subunits. It seems reliant on NR2B [1] for its antidepressant effect. It has an approx dose of 300-500mcg Oral/IN with a half-life of 1-2 hours but with significant antidepressant and anxiolytic effects lasting over a week.

It is the third generation preceeding from Apimostinel, and is a small molecule. Compared to Rapastinel, Zelquistinel is many times more potent and is intended as an improved, follow-up drug to the original Rapastinel and Apimostinel.

Unlike Rapastinel, Zelquistinel is orally bioavailable, exhibits increased potency, and has improved drug properties.

Note: Quite difficult to make.