PDE Enzyme Group

A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below.

PDEs have found significance for many neurological disorders, normally neurodegeneration-related, such as schizophrenia and Alzheimer's. PDEs have very general interactions, with neurological and physiological interactions occuring differently on the many subtypes.

cAMP / cGMP Specifity

Both

• PDE1
• PDE2
• PDE3
• PDE10
• PDE11

cAMP

• PDE4 (most significant for cognition)
• PDE7
• PDE8

cGMP

• PDE5
• PDE6
• PDE9