A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below.
PDEs have found significance for many neurological disorders, normally neurodegeneration-related, such as schizophrenia and Alzheimer's. PDEs have very general interactions, with neurological and physiological interactions occuring differently on the many subtypes.
cAMP / cGMP Specifity
Both
- PDE1
- PDE2
- PDE3
- PDE10
- PDE11
cAMP
- PDE4 (most significant for cognition)
- PDE7
- PDE8
cGMP
- PDE5
- PDE6
- PDE9