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Luvadaxistat

Primary Mechanism DAAO Inhibitor
Class Nootropic
Drug Status Phase 2
Alternate Names TAK-831
Pubchem ID 71270546
Contributors @arche

Pharmacology

Luvadaxistat is an experimental drug that works as a D-amino acid oxidase (DAAO) inhibitor, which increases D-Serine in the brain [1].

Because its mechanism avoids potentiating NR3 like binding to the glycine site of NMDA may, and because Luvadaxistat potentiates endogenous D-Serine (and its special properties), it is likely superior to Neboglamine and D-cycloserine.

D-Serine levels (mean ± SEM, n = 5) in cerebellum of male Wistar rats pre-treated with luvadaxistat 1, 3, and 10 mg/kg p.o. at 2, 6, 10, and 24 h [1]

Sources

[ 1 ] Luvadaxistat: A Novel Potent and Selective d-Amino Acid Oxidase Inhibitor Improves Cognitive and Social Deficits in Rodent Models for Schizophrenia

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